Selective Modules

Critical Care Research Literacy

A primer on modern critical care research methodology — trial design, bias, effect measures, and critically appraising ICU evidence for the bedside.

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Learning Objectives

[DRAFT — KEVIN TO REVIEW] Distinguish common ICU trial designs, including individual randomized, cluster-randomized, adaptive, and platform trials.
[DRAFT — KEVIN TO REVIEW] Interpret relative and absolute effect measures, uncertainty, and clinical importance using RR, OR, ARR, NNT, and confidence intervals.
[DRAFT — KEVIN TO REVIEW] Identify major sources of bias and explain how randomization, allocation concealment, blinding, prespecified analysis, and complete follow-up mitigate them.
[DRAFT — KEVIN TO REVIEW] Compare pragmatic and explanatory trials and judge whether a study population, intervention, comparator, and setting apply to an individual ICU patient.
[DRAFT — KEVIN TO REVIEW] Differentiate surrogate outcomes from patient-centered outcomes and assess whether the selected endpoint supports a bedside decision.
[DRAFT — KEVIN TO REVIEW] Interpret frequentist and Bayesian results without reducing evidence appraisal to statistical significance alone.